<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <link:roleRef roleURI="http://www.twilio.com/role/CoverPage" xlink:href="twlo-20200205.xsd#CoverPage" xlink:type="simple" />
  <link:roleRef roleURI="http://www.twilio.com/role/CoverPageNonPrinting" xlink:href="twlo-20200205.xsd#CoverPageNonPrinting" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" xlink:type="simple" />
  <link:presentationLink xlink:role="http://www.twilio.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:href="twlo-20200205.xsd#twlo_CoverPageAbstract" xlink:label="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:type="locator" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressesTable" xlink:label="loc_dei_EntityAddressesTable_FEABDD89A44058AFBA9A9F871620098F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_EntityAddressesTable_FEABDD89A44058AFBA9A9F871620098F" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_9B417E18E810549FA3F8BD756D422B1F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityAddressesTable_FEABDD89A44058AFBA9A9F871620098F" xlink:to="loc_dei_LegalEntityAxis_9B417E18E810549FA3F8BD756D422B1F" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_581D825E7CE65C38AE960F9A06745ABF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_9B417E18E810549FA3F8BD756D422B1F" xlink:to="loc_dei_EntityDomain_581D825E7CE65C38AE960F9A06745ABF" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressesAddressTypeAxis" xlink:label="loc_dei_EntityAddressesAddressTypeAxis_F2CC3BC8D2995266B210D4ADEC193F3D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityAddressesTable_FEABDD89A44058AFBA9A9F871620098F" xlink:to="loc_dei_EntityAddressesAddressTypeAxis_F2CC3BC8D2995266B210D4ADEC193F3D" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_AddressTypeDomain" xlink:label="loc_dei_AddressTypeDomain_EDC21E8E0856502D82D7A370A15E2AD8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityAddressesAddressTypeAxis_F2CC3BC8D2995266B210D4ADEC193F3D" xlink:to="loc_dei_AddressTypeDomain_EDC21E8E0856502D82D7A370A15E2AD8" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_FormerAddressMember" xlink:label="loc_dei_FormerAddressMember_B1D8A215A7B052599E2936818E4C5AEC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_AddressTypeDomain_EDC21E8E0856502D82D7A370A15E2AD8" xlink:to="loc_dei_FormerAddressMember_B1D8A215A7B052599E2936818E4C5AEC" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressesLineItems" xlink:label="loc_dei_EntityAddressesLineItems_83F27FA3D17354C0A581630616AAC807" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityAddressesTable_FEABDD89A44058AFBA9A9F871620098F" xlink:to="loc_dei_EntityAddressesLineItems_83F27FA3D17354C0A581630616AAC807" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine1" xlink:label="loc_dei_EntityAddressAddressLine1_B6C8DFA0AB3F5606B7D6CD7E8EC5FEC7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityAddressesLineItems_83F27FA3D17354C0A581630616AAC807" xlink:to="loc_dei_EntityAddressAddressLine1_B6C8DFA0AB3F5606B7D6CD7E8EC5FEC7" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine2" xlink:label="loc_dei_EntityAddressAddressLine2_0F7EF318DE9C57F78FFDAFF8D014B49B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityAddressesLineItems_83F27FA3D17354C0A581630616AAC807" xlink:to="loc_dei_EntityAddressAddressLine2_0F7EF318DE9C57F78FFDAFF8D014B49B" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressCityOrTown" xlink:label="loc_dei_EntityAddressCityOrTown_B92D63C5C0ED58A2B4A74189C833758C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityAddressesLineItems_83F27FA3D17354C0A581630616AAC807" xlink:to="loc_dei_EntityAddressCityOrTown_B92D63C5C0ED58A2B4A74189C833758C" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressStateOrProvince" xlink:label="loc_dei_EntityAddressStateOrProvince_CDF8E6834DAD518FA38A567ED8372FB1" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityAddressesLineItems_83F27FA3D17354C0A581630616AAC807" xlink:to="loc_dei_EntityAddressStateOrProvince_CDF8E6834DAD518FA38A567ED8372FB1" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressPostalZipCode" xlink:label="loc_dei_EntityAddressPostalZipCode_A717BC26C7D55341B7D2F87945C13561" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityAddressesLineItems_83F27FA3D17354C0A581630616AAC807" xlink:to="loc_dei_EntityAddressPostalZipCode_A717BC26C7D55341B7D2F87945C13561" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_261EACC3C8EE55658E2EC275179CF8C7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_DocumentType_261EACC3C8EE55658E2EC275179CF8C7" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_D15A83773CB454C8BC00DCF1195A5A8A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_DocumentPeriodEndDate_D15A83773CB454C8BC00DCF1195A5A8A" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_B98A72A480AC54BF90093000A4DBF5F5" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_EntityRegistrantName_B98A72A480AC54BF90093000A4DBF5F5" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityIncorporationStateCountryCode" xlink:label="loc_dei_EntityIncorporationStateCountryCode_515FDFB03AFE558CB5F9DD2683BAAC89" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_EntityIncorporationStateCountryCode_515FDFB03AFE558CB5F9DD2683BAAC89" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFileNumber" xlink:label="loc_dei_EntityFileNumber_5B1F98173FFD55B4891D27A71D9F557D" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_EntityFileNumber_5B1F98173FFD55B4891D27A71D9F557D" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityTaxIdentificationNumber" xlink:label="loc_dei_EntityTaxIdentificationNumber_9347EBEA97315B49B718EC0879A6ECAA" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_EntityTaxIdentificationNumber_9347EBEA97315B49B718EC0879A6ECAA" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CityAreaCode" xlink:label="loc_dei_CityAreaCode_53E20CA3102E5003B7F4F2CF38E7BF9E" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_CityAreaCode_53E20CA3102E5003B7F4F2CF38E7BF9E" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LocalPhoneNumber" xlink:label="loc_dei_LocalPhoneNumber_B79E45729996557C9E39FC88F49207FE" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_LocalPhoneNumber_B79E45729996557C9E39FC88F49207FE" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_WrittenCommunications" xlink:label="loc_dei_WrittenCommunications_09B78B3CFF515289AE83EDA1BCDC0501" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_WrittenCommunications_09B78B3CFF515289AE83EDA1BCDC0501" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SolicitingMaterial" xlink:label="loc_dei_SolicitingMaterial_DBBA170D7BDC569095213334B6ED89F0" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_SolicitingMaterial_DBBA170D7BDC569095213334B6ED89F0" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementTenderOffer" xlink:label="loc_dei_PreCommencementTenderOffer_5EBDBC4248FF531C95EE6AE741024D60" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_PreCommencementTenderOffer_5EBDBC4248FF531C95EE6AE741024D60" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementIssuerTenderOffer" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_4FD6657EF94250C99EA374C6F131F7CB" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_4FD6657EF94250C99EA374C6F131F7CB" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_Security12bTitle" xlink:label="loc_dei_Security12bTitle_4C46678D45A85DBAA688447BA7867DD8" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_Security12bTitle_4C46678D45A85DBAA688447BA7867DD8" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_TradingSymbol" xlink:label="loc_dei_TradingSymbol_DCA77C295B215AE4ACD3776132428528" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_TradingSymbol_DCA77C295B215AE4ACD3776132428528" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SecurityExchangeName" xlink:label="loc_dei_SecurityExchangeName_01F0E6A755E15881864C7C77F6015514" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_SecurityExchangeName_01F0E6A755E15881864C7C77F6015514" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityEmergingGrowthCompany" xlink:label="loc_dei_EntityEmergingGrowthCompany_E43C2497F5ED5487831D5437C261CA26" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_912C291C4E5B5B47A6C0071CBEF19014" xlink:to="loc_dei_EntityEmergingGrowthCompany_E43C2497F5ED5487831D5437C261CA26" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.twilio.com/role/CoverPageNonPrinting" xlink:type="extended">
    <link:loc xlink:href="twlo-20200205.xsd#twlo_CoverPageAbstract" xlink:label="loc_twlo_CoverPageAbstract_7095DB69224A5AC69D1B193F21417375" xlink:type="locator" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_13A2E36CA9AE5ECC9AE14E2F16ADE4D0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_7095DB69224A5AC69D1B193F21417375" xlink:to="loc_dei_EntityCentralIndexKey_13A2E36CA9AE5ECC9AE14E2F16ADE4D0" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_F5EBF1988CAE5D38B66AA73280F6933F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_twlo_CoverPageAbstract_7095DB69224A5AC69D1B193F21417375" xlink:to="loc_dei_AmendmentFlag_F5EBF1988CAE5D38B66AA73280F6933F" xlink:type="arc" />
  </link:presentationLink>
</link:linkbase>
