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  <xs:element id="twlo_APICShareBasedPaymentArrangementIncreaseForCostRecognitionRestructuring" abstract="false" name="APICShareBasedPaymentArrangementIncreaseForCostRecognitionRestructuring" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="twlo_ConversionOfStockSharesConvertedConversionRatio" abstract="false" name="ConversionOfStockSharesConvertedConversionRatio" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="twlo_ValueFirstBusinessMember" abstract="true" name="ValueFirstBusinessMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="twlo_DanaWagnerUpdatedArrangementMember" abstract="true" name="DanaWagnerUpdatedArrangementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="twlo_ClassACommonStockAndRestrictedStockSubjectToFutureVestingMember" abstract="true" name="ClassACommonStockAndRestrictedStockSubjectToFutureVestingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
</xs:schema>
