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  <xs:element id="twlo_EquityAwardsAssumedDuringPeriodValue" abstract="false" name="EquityAwardsAssumedDuringPeriodValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="twlo_APICShareBasedPaymentArrangementIncreaseForCostRecognitionRestructuring" abstract="false" name="APICShareBasedPaymentArrangementIncreaseForCostRecognitionRestructuring" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="twlo_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsFairValueOfCommonStock" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsFairValueOfCommonStock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="twlo_CommonStockCapitalSharesReservedForFutureIssuanceTableTextBlock" abstract="false" name="CommonStockCapitalSharesReservedForFutureIssuanceTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="twlo_LesseeOperatingLeaseNumberOfContracts" abstract="false" name="LesseeOperatingLeaseNumberOfContracts" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="twlo_StockIssuedDuringPeriodSharesSubjectToFutureVestingConditions" abstract="false" name="StockIssuedDuringPeriodSharesSubjectToFutureVestingConditions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="twlo_ZipwhipMember" abstract="true" name="ZipwhipMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="twlo_UsageBasedContractsMember" abstract="true" name="UsageBasedContractsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="twlo_RevenueRecognitionPeriodAxis" abstract="true" name="RevenueRecognitionPeriodAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
</xs:schema>
