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        <link:definition>2409402 - Disclosure - Notes Payable - Issuance (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="NotesPayableNetCarryingAmountDetails" roleURI="http://www.twilio.com/role/NotesPayableNetCarryingAmountDetails">
        <link:definition>2409404 - Disclosure - Notes Payable - Net Carrying Amount (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="NotesPayableNotePayableDetails" roleURI="http://www.twilio.com/role/NotesPayableNotePayableDetails">
        <link:definition>2409407 - Disclosure - Notes Payable - Note Payable (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
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      <link:roleType id="NotesPayableTables" roleURI="http://www.twilio.com/role/NotesPayableTables">
        <link:definition>2309301 - Disclosure - Notes Payable (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="NotesPayableTermsDetails" roleURI="http://www.twilio.com/role/NotesPayableTermsDetails">
        <link:definition>2409403 - Disclosure - Notes Payable - Terms (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="OrganizationAndDescriptionOfBusiness" roleURI="http://www.twilio.com/role/OrganizationAndDescriptionOfBusiness">
        <link:definition>2101100 - Disclosure - Organization and Description of Business</link:definition>
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      <link:roleType id="PropertyAndEquipment" roleURI="http://www.twilio.com/role/PropertyAndEquipment">
        <link:definition>2104100 - Disclosure - Property and Equipment</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="PropertyAndEquipmentCapitalizedSoftwareDevelopmentCostsDetails" roleURI="http://www.twilio.com/role/PropertyAndEquipmentCapitalizedSoftwareDevelopmentCostsDetails">
        <link:definition>2404404 - Disclosure - Property and Equipment - Capitalized Software Development Costs (Details)</link:definition>
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      <link:roleType id="PropertyAndEquipmentDepreciationAndAmortizationExpenseDetails" roleURI="http://www.twilio.com/role/PropertyAndEquipmentDepreciationAndAmortizationExpenseDetails">
        <link:definition>2404403 - Disclosure - Property and Equipment - Depreciation and Amortization Expense (Details)</link:definition>
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      <link:roleType id="PropertyAndEquipmentPropertyAndEquipmentNetDetails" roleURI="http://www.twilio.com/role/PropertyAndEquipmentPropertyAndEquipmentNetDetails">
        <link:definition>2404402 - Disclosure - Property and Equipment - Property and Equipment, Net (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="PropertyAndEquipmentTables" roleURI="http://www.twilio.com/role/PropertyAndEquipmentTables">
        <link:definition>2304301 - Disclosure - Property and Equipment (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="RevenueByGeographicArea" roleURI="http://www.twilio.com/role/RevenueByGeographicArea">
        <link:definition>2111100 - Disclosure - Revenue by Geographic Area</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="RevenueByGeographicAreaPercentageOfRevenueByGeographicAreaDetails" roleURI="http://www.twilio.com/role/RevenueByGeographicAreaPercentageOfRevenueByGeographicAreaDetails">
        <link:definition>2411403 - Disclosure - Revenue by Geographic Area - Percentage of Revenue by Geographic Area (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="RevenueByGeographicAreaRevenueByGeographicAreaDetails" roleURI="http://www.twilio.com/role/RevenueByGeographicAreaRevenueByGeographicAreaDetails">
        <link:definition>2411402 - Disclosure - Revenue by Geographic Area - Revenue by Geographic Area (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="RevenueByGeographicAreaTables" roleURI="http://www.twilio.com/role/RevenueByGeographicAreaTables">
        <link:definition>2311301 - Disclosure - Revenue by Geographic Area (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="RightOfUseAssetAndLeaseLiabilities" roleURI="http://www.twilio.com/role/RightOfUseAssetAndLeaseLiabilities">
        <link:definition>2105100 - Disclosure - Right-of-Use Asset and Lease Liabilities</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="RightOfUseAssetAndLeaseLiabilitiesBalanceSheetClassificationOfLeaseAssetsAndLiabilitiesDetails" roleURI="http://www.twilio.com/role/RightOfUseAssetAndLeaseLiabilitiesBalanceSheetClassificationOfLeaseAssetsAndLiabilitiesDetails">
        <link:definition>2405404 - Disclosure - Right-of-Use Asset and Lease Liabilities - Balance Sheet Classification of Lease Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
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      <link:roleType id="RightOfUseAssetAndLeaseLiabilitiesComponentsOfLeaseExpenseDetails" roleURI="http://www.twilio.com/role/RightOfUseAssetAndLeaseLiabilitiesComponentsOfLeaseExpenseDetails">
        <link:definition>2405403 - Disclosure - Right-of-Use Asset and Lease Liabilities - Components of Lease Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
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      <link:roleType id="RightOfUseAssetAndLeaseLiabilitiesLeaseMaturitiesDetails" roleURI="http://www.twilio.com/role/RightOfUseAssetAndLeaseLiabilitiesLeaseMaturitiesDetails">
        <link:definition>2405406 - Disclosure - Right-of-Use Asset and Lease Liabilities - Lease Maturities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="RightOfUseAssetAndLeaseLiabilitiesLeaseMaturitiesDetailsCalc2" roleURI="http://www.twilio.com/role/RightOfUseAssetAndLeaseLiabilitiesLeaseMaturitiesDetailsCalc2">
        <link:definition>2405406 - Disclosure - Right-of-Use Asset and Lease Liabilities - Lease Maturities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="RightOfUseAssetAndLeaseLiabilitiesLeaseMaturitiesPriorToAdoptionOfNewLeaseStandardDetails" roleURI="http://www.twilio.com/role/RightOfUseAssetAndLeaseLiabilitiesLeaseMaturitiesPriorToAdoptionOfNewLeaseStandardDetails">
        <link:definition>2405407 - Disclosure - Right-of-Use Asset and Lease Liabilities - Lease Maturities Prior To Adoption of New Lease Standard (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="RightOfUseAssetAndLeaseLiabilitiesNarrativeDetails" roleURI="http://www.twilio.com/role/RightOfUseAssetAndLeaseLiabilitiesNarrativeDetails">
        <link:definition>2405402 - Disclosure - Right-of-Use Asset and Lease Liabilities - Narrative (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="RightOfUseAssetAndLeaseLiabilitiesSupplementalCashFlowsDetails" roleURI="http://www.twilio.com/role/RightOfUseAssetAndLeaseLiabilitiesSupplementalCashFlowsDetails">
        <link:definition>2405405 - Disclosure - Right-of-Use Asset and Lease Liabilities - Supplemental Cash Flows (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="RightOfUseAssetAndLeaseLiabilitiesTables" roleURI="http://www.twilio.com/role/RightOfUseAssetAndLeaseLiabilitiesTables">
        <link:definition>2305301 - Disclosure - Right-of-Use Asset and Lease Liabilities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>2114100 - Disclosure - Stock-Based Compensation</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>2414402 - Disclosure - Stock-Based Compensation - 2008 Stock Option Plan (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>2414404 - Disclosure - Stock-Based Compensation - 2016 Employee Stock Purchase Plan (Details)</link:definition>
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        <link:definition>2414403 - Disclosure - Stock-Based Compensation - 2016 Stock Option Plan (Details)</link:definition>
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        <link:definition>2414407 - Disclosure - Stock-Based Compensation - Performance-Based Stock Options (Details)</link:definition>
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        <link:definition>2414409 - Disclosure - Stock-Based Compensation - Restricted Stock Units Activity (Details)</link:definition>
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        <link:definition>2414410 - Disclosure - Stock-Based Compensation - Restricted Stock Units - Unrecognized Compensation Cost (Details)</link:definition>
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        <link:definition>2414412 - Disclosure - Stock-Based Compensation - Stock-Based Compensation Expense (Details)</link:definition>
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        <link:definition>2414405 - Disclosure - Stock-Based Compensation - Stock Option Activity (Details)</link:definition>
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        <link:definition>2414406 - Disclosure - Stock-Based Compensation - Stock Options - Additional Information (Details)</link:definition>
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        <link:definition>2414408 - Disclosure - Stock-Based Compensation - Stock Options - Unrecognized Compensation Cost (Details)</link:definition>
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        <link:definition>2314301 - Disclosure - Stock-Based Compensation (Tables)</link:definition>
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        <link:definition>2414411 - Disclosure - Stock-Based Compensation - Valuation Assumptions (Details)</link:definition>
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        <link:definition>2113100 - Disclosure - Stockholders' Equity</link:definition>
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        <link:definition>2413403 - Disclosure - Stockholders' Equity - Common Stock (Details)</link:definition>
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        <link:definition>2413404 - Disclosure - Stockholders' Equity - Common Stock Shares Reserved (Details)</link:definition>
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        <link:definition>2413402 - Disclosure - Stockholders' Equity - Preferred Stock (Details)</link:definition>
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        <link:definition>2413405 - Disclosure - Stockholders' Equity Stockholders' Equity - Follow-on Public Offering (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="StockholdersEquityTables" roleURI="http://www.twilio.com/role/StockholdersEquityTables">
        <link:definition>2313301 - Disclosure - Stockholders' Equity (Tables)</link:definition>
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      <link:roleType id="SummaryOfSignificantAccountingPolicies" roleURI="http://www.twilio.com/role/SummaryOfSignificantAccountingPolicies">
        <link:definition>2102100 - Disclosure - Summary of Significant Accounting Policies</link:definition>
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        <link:definition>2402404 - Disclosure - Summary of Significant Accounting Policies - Deferred Sales Commissions (Details)</link:definition>
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        <link:definition>2202201 - Disclosure - Summary of Significant Accounting Policies (Policies)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>2402405 - Disclosure - Summary of Significant Accounting Policies - Recent Accounting Guidance (Details)</link:definition>
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        <link:definition>2402403 - Disclosure - Summary of Significant Accounting Policies - Revenue Recognition (Details)</link:definition>
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        <link:definition>2110100 - Disclosure - Supplemental Balance Sheet Information</link:definition>
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        <link:definition>2410402 - Disclosure - Supplemental Balance Sheet Information - Allowance for Doubtful Accounts (Details)</link:definition>
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        <link:definition>2410403 - Disclosure - Supplemental Balance Sheet Information - Sales Credit Reserve (Details)</link:definition>
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        <link:definition>2310301 - Disclosure - Supplemental Balance Sheet Information (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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  <xsd:element id="twlo_AdjustmentToAdditionalPaidInCapitalVestingOfEarlyExercisedStockOptions" name="AdjustmentToAdditionalPaidInCapitalVestingOfEarlyExercisedStockOptions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="twlo_AdjustmentsToAdditionalPaidInCapitalCappedCallOptionIssuanceCosts" name="AdjustmentsToAdditionalPaidInCapitalCappedCallOptionIssuanceCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="twlo_AdjustmentsToAdditionalPaidInCapitalDebtConversionOptionIssuanceCosts" name="AdjustmentsToAdditionalPaidInCapitalDebtConversionOptionIssuanceCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="twlo_AllowanceForDoubtfulAccountPercentOfRevenue" name="AllowanceForDoubtfulAccountPercentOfRevenue" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_AssetsAndLiabilitiesLesseeTableTextBlock" name="AssetsAndLiabilitiesLesseeTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoAmortizedCostBasis" name="AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoAmortizedCostBasis" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="twlo_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoFairValue" name="AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoFairValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="twlo_BusinessCombinationConsiderationHoldbackNonCurrent" name="BusinessCombinationConsiderationHoldbackNonCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="twlo_BusinessCombinationConsiderationTransferredAmountHeldForTaxLiabilities" name="BusinessCombinationConsiderationTransferredAmountHeldForTaxLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="twlo_BusinessCombinationConsiderationTransferredAmountPlacedInEscrow" name="BusinessCombinationConsiderationTransferredAmountPlacedInEscrow" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="twlo_BusinessCombinationConsiderationTransferredEscrowPeriod" name="BusinessCombinationConsiderationTransferredEscrowPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_BusinessCombinationConsiderationWithheld" name="BusinessCombinationConsiderationWithheld" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="twlo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseAssets" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="twlo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinanceLeaseLiability" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinanceLeaseLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="twlo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinanceRightOfUseAssets" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedFinanceRightOfUseAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="twlo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNetExcludingIntangibleAssets" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNetExcludingIntangibleAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="twlo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseLiability" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="twlo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingRightOfUseAssets" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingRightOfUseAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="twlo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedReleaseOfValuationAllowanceOnDeferredTaxAssets" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedReleaseOfValuationAllowanceOnDeferredTaxAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="twlo_BusinessCombinationShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateGrantValue" name="BusinessCombinationShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateGrantValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="twlo_BusinessCombinationShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" name="BusinessCombinationShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_BusinessCombinationShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms" name="BusinessCombinationShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_CapioIncMember" name="CapioIncMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_CappedCallOptionMember" name="CappedCallOptionMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_CashPaidOnFinanceLeases" name="CashPaidOnFinanceLeases" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="twlo_CommonStockCapitalSharesReservedForConvertibleDebt" name="CommonStockCapitalSharesReservedForConvertibleDebt" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="twlo_CommonStockCapitalSharesReservedForFutureIssuanceDonorAdvisedFund" name="CommonStockCapitalSharesReservedForFutureIssuanceDonorAdvisedFund" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="twlo_CommonStockCapitalSharesReservedForFutureIssuanceTableTextBlock" name="CommonStockCapitalSharesReservedForFutureIssuanceTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_CommonStockVotesPerShare" name="CommonStockVotesPerShare" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="twlo_ContractWithCustomerLiabilityPromotionsMember" name="ContractWithCustomerLiabilityPromotionsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_ConversionSpreadMember" name="ConversionSpreadMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_ConvertibleNotesPayableEquityComponentAbstract" name="ConvertibleNotesPayableEquityComponentAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_ConvertibleSeniorNotes0.25PercentDue2023Member" name="ConvertibleSeniorNotes0.25PercentDue2023Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_ConvertibleSeniorNotes0.25PercentDue2023OverAllotmentMember" name="ConvertibleSeniorNotes0.25PercentDue2023OverAllotmentMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_CorporateDebtSecuritiesCommercialPaperMember" name="CorporateDebtSecuritiesCommercialPaperMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_DebtInstrumentConversionEligibilityBasedOnDebtTradingPriceConsecutiveTradingDays" name="DebtInstrumentConversionEligibilityBasedOnDebtTradingPriceConsecutiveTradingDays" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_DebtInstrumentConversionEligibilityBasedOnDebtTradingPriceThresholdPercentageForEligibility" name="DebtInstrumentConversionEligibilityBasedOnDebtTradingPriceThresholdPercentageForEligibility" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_DebtInstrumentConvertibleCarryingAmountOfEquityComponentNetOfIssuanceCosts" name="DebtInstrumentConvertibleCarryingAmountOfEquityComponentNetOfIssuanceCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="twlo_DebtSecuritiesAvailableForSalePrivatelyHeldAmortizedCost" name="DebtSecuritiesAvailableForSalePrivatelyHeldAmortizedCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="twlo_DonorAdvisedFundMember" name="DonorAdvisedFundMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_EmployeeAndNonemployeeStockOptionIncludingPerformanceBasedOptionsMember" name="EmployeeAndNonemployeeStockOptionIncludingPerformanceBasedOptionsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_EmployeeAndNonemployeeStockOptionMember" name="EmployeeAndNonemployeeStockOptionMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_EquityAwardsAssumedDuringPeriodValue" name="EquityAwardsAssumedDuringPeriodValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="twlo_FinancialAssetsAmortizedCostOrCarryingValue" name="FinancialAssetsAmortizedCostOrCarryingValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="twlo_FollowonPublicOfferingDomain" name="FollowonPublicOfferingDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_GoodwillPurchaseAccountingAdjustmentsNet" name="GoodwillPurchaseAccountingAdjustmentsNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="twlo_IncreaseDecreaseInOperatingLeaseLiability" name="IncreaseDecreaseInOperatingLeaseLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_IncrementalCommissionCostsOfObtainingNewContractsMember" name="IncrementalCommissionCostsOfObtainingNewContractsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_LeaseLiability" name="LeaseLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="twlo_LeaseRightOfUseAsset" name="LeaseRightOfUseAsset" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="twlo_LesseeFinanceLeaseAccumulatedDepreciation" name="LesseeFinanceLeaseAccumulatedDepreciation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="twlo_LesseeFinanceLeaseLeaseNotYetCommencedLiability" name="LesseeFinanceLeaseLeaseNotYetCommencedLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="twlo_LesseeLeaseLeaseNotYetCommencedTermOfContract" name="LesseeLeaseLeaseNotYetCommencedTermOfContract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_LesseeOperatingLeaseAccumulatedAmortization" name="LesseeOperatingLeaseAccumulatedAmortization" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="twlo_LesseeOperatingLeaseLeaseNotYetCommencedLiability" name="LesseeOperatingLeaseLeaseNotYetCommencedLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="twlo_LossContingencyNumberOfClassOfIndividualsSentOrReceivedCommunications" name="LossContingencyNumberOfClassOfIndividualsSentOrReceivedCommunications" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element id="twlo_LossContingencyNumberOfCustomersAccountsInvolvedInLitigationCase" name="LossContingencyNumberOfCustomersAccountsInvolvedInLitigationCase" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="twlo_NewHiresMember" name="NewHiresMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_OptionIndexedToIssuersEquityCapPrice" name="OptionIndexedToIssuersEquityCapPrice" nillable="true" substitutionGroup="xbrli:item" type="num:perShareItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_OverAllotmentOptionFPODomain" name="OverAllotmentOptionFPODomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_PaymentsForCappedCallOptions" name="PaymentsForCappedCallOptions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_PerformanceBasedEmployeeStockOptions10.26FairValueMember" name="PerformanceBasedEmployeeStockOptions10.26FairValueMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_PerformanceBasedEmployeeStockOptions13.48FairValueMember" name="PerformanceBasedEmployeeStockOptions13.48FairValueMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_PerformanceBasedEmployeeStockOptions8.41FairValueMember" name="PerformanceBasedEmployeeStockOptions8.41FairValueMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_PerformanceBasedEmployeeStockOptionsMember" name="PerformanceBasedEmployeeStockOptionsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_ProvisionForDoubtfulAccountsAndOther" name="ProvisionForDoubtfulAccountsAndOther" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="twlo_ProvisionForDoubtfulAccountsAssumedInAcquisition" name="ProvisionForDoubtfulAccountsAssumedInAcquisition" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="twlo_PurchasesOfPropertyEquipmentAndIntangibleAssetsAccruedButNotPaid" name="PurchasesOfPropertyEquipmentAndIntangibleAssetsAccruedButNotPaid" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="twlo_PurchasesOfPropertyEquipmentThroughFinancingLease" name="PurchasesOfPropertyEquipmentThroughFinancingLease" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_ReverseRepurchaseAgreementMember" name="ReverseRepurchaseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_SalesCreditReservePercentOfRevenue" name="SalesCreditReservePercentOfRevenue" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_SalesCreditReserveTableTextBlock" name="SalesCreditReserveTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_ScheduleOfAccruedExpensesAndOtherCurrentLiabilitiesTableTextBlock" name="ScheduleOfAccruedExpensesAndOtherCurrentLiabilitiesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_ScheduleOfIntangibleAssetsExcludingGoodwillTableTextBlock" name="ScheduleOfIntangibleAssetsExcludingGoodwillTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_ScheduleOfInterestOnConvertibleDebtTableTextBlock" name="ScheduleOfInterestOnConvertibleDebtTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_SendgridIncMember" name="SendgridIncMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAssumedInPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAssumedInPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAssumedInPeriodWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAssumedInPeriodWeightedAverageGrantDateFairValue" nillable="true" substitutionGroup="xbrli:item" type="num:perShareItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAssetVolatility" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAssetVolatility" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsEquityVolatility" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsEquityVolatility" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsFairValueOfCommonStock" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsFairValueOfCommonStock" nillable="true" substitutionGroup="xbrli:item" type="num:perShareItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_ShareBasedCompensationArrangementByShareBasedPaymentAwardGrantPriceAsPercentageOfFairMarketValueOfCommonStockMinimum" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardGrantPriceAsPercentageOfFairMarketValueOfCommonStockMinimum" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant" />
  <xsd:element id="twlo_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumAnnualIncreaseInAuthorizationPercentageOfOutstandingShares" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumAnnualIncreaseInAuthorizationPercentageOfOutstandingShares" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant" />
  <xsd:element id="twlo_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumAnnualIncreaseInNumberOfSharesAuthorized" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumAnnualIncreaseInNumberOfSharesAuthorized" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="twlo_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfDistinctAwards" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfDistinctAwards" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodTotalGrantValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodTotalGrantValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="twlo_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsSharesAssumedInAcquisition" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsSharesAssumedInAcquisition" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_ShareBasedCompensationArrangementByShareBasedPaymentAwardPerformanceConditionPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPerformanceConditionPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_ShareBasedCompensationArrangementByShareBasedPaymentAwardVestingPeriodAfterSatisfactionOfPerformanceCondition" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardVestingPeriodAfterSatisfactionOfPerformanceCondition" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsSharesAssumedInAcquisitionWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsSharesAssumedInAcquisitionWeightedAverageExercisePrice" nillable="true" substitutionGroup="xbrli:item" type="num:perShareItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_SoftwareNotIncludingSoftwareDevelopmentCostsMember" name="SoftwareNotIncludingSoftwareDevelopmentCostsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_StockIssuedDuringPeriodSharesStockOptionsExercisedUnvested" name="StockIssuedDuringPeriodSharesStockOptionsExercisedUnvested" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_StockOptionAndIncentivePlan2016Member" name="StockOptionAndIncentivePlan2016Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_StockOptionPlan2008Member" name="StockOptionPlan2008Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_SupplierRelationshipsMember" name="SupplierRelationshipsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_UnrecognizedTaxBenefitsIncreaseResultingfromOngoingBenefit" name="UnrecognizedTaxBenefitsIncreaseResultingfromOngoingBenefit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="twlo_UnrecordedUnconditionalPurchaseObligationsAdditions" name="UnrecordedUnconditionalPurchaseObligationsAdditions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_UnvestedSharesSubjectToRepurchaseMember" name="UnvestedSharesSubjectToRepurchaseMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="twlo_ValuationAllowancesAndReservesChargedToOtherAccountsAssumedInAcquisition" name="ValuationAllowancesAndReservesChargedToOtherAccountsAssumedInAcquisition" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_WeightedAverageDiscountRateAbstract" name="WeightedAverageDiscountRateAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="twlo_WeightedAverageRemainingLeaseTermAbstract" name="WeightedAverageRemainingLeaseTermAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
</xsd:schema>
</XBRL>
