November 29, 2018

Jeff Lawson
Chief Excecutive Officer
Twilio Inc.
375 Beale Street, Suite 300
San Francisco, CA 94105

       Re: Twilio Inc.
           Registration Statement on Form S-4
           Filed November 21, 2018
           File No. 333-228522

Dear Mr. Lawson:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

      Please contact Edwin Kim, Attorney-Advisor, at (202) 551-3297 or Jan Woo,
Legal
Branch Chief, at (202) 551-3453 with any questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of
Information Technologies
                                                            and Services
cc:    Blake Liggio, Esq.